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Caption | Gonads from age matched Ror2tm1Ymi/Ror2tm1Ymi (Ror2-/-) and wild-type (WT) littermates on the C57BL/6 background were stained in whole mount with germ cell nuclear antigen (GCNA) antibody and primordial germ cells (PGCs) quantified from confocal stacks. A significant depletion was observed in homozygous mutants (purple triangles) compared to WT (black diamonds) at E11.25 and E12.25 (A). At E11.5, compared to WT (B), Ror2tm1Ymi/Ror2tm1Ymi (C) gonads exhibit a skewed distribution of PGCs at the posterior (bottom), similar to Ror2Y324C/Ror2Y324C mice. | ||||
Copyright | This image is from Laird DJ, PLoS Genet 2011 Dec;7(12):e1002428, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179805 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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