Phenotype Image Detail

Image

Caption

Gonads from age matched Ror2^tm1Ymi/Ror2^tm1Ymi (Ror2-/-) and wild-type (WT) littermates on the C57BL/6 background were stained in whole mount with germ cell nuclear antigen (GCNA) antibody and primordial germ cells (PGCs) quantified from confocal stacks. A significant depletion was observed in homozygous mutants (purple triangles) compared to WT (black diamonds) at E11.25 and E12.25 (A). At E11.5, compared to WT (B), Ror2^tm1Ymi/Ror2^tm1Ymi (C) gonads exhibit a skewed distribution of PGCs at the posterior (bottom), similar to Ror2^Y324C/Ror2^Y324C mice.

Copyright

This image is from Laird DJ, PLoS Genet 2011 Dec;7(12):e1002428, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179805

Associated Alleles

Symbol	Name
Ror2^tm1Ymi	receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, Yasuhiro Minami

Associated Genotypes

Allelic Composition	Genetic Background
Ror2^tm1Ymi/Ror2^tm1Ymi	involves: 129P2/OlaHsd * C57BL/6