Phenotype Image Detail

Image

Caption

ABHD5 (CGI-58) deficiency disrupts the epidermal permeability barrier and affects keratinocyte differentiation. A, euthanized newborn wild-type, Abhd5^tm1.1Rze/Abhd5^tm1.1Rze (Cgi-58-/-), and Pnpla2^tm1Rze/Pnpla2^tm1Rze (Atgl-/-) mice were immersed for 4 hours in toluidine blue dye solution, rinsed with PBS, and photographed. B, skin sections of newborn wild-type and Abhd5^tm1.1Rze/Abhd5^tm1.1Rze mice were stained with antibodies specific for cytokeratin 14 (CK14), cytokeratin 6 (CK6), fillagrin (Fila), or Ki67 and analyzed by light microscopy. Scale bars represent 50 um.

Copyright

This image is from Radner FP, J Biol Chem 2010 Mar 5;285(10):7300-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:160725

Associated Alleles

Symbol	Name
Abhd5^tm1.1Rze	abhydrolase domain containing 5; targeted mutation 1.1, Rudolf Zechner
Pnpla2^tm1Rze	patatin-like phospholipase domain containing 2; targeted mutation 1, Rudolf Zechner

Associated Genotypes

Allelic Composition	Genetic Background
Abhd5^tm1.1Rze/Abhd5^tm1.1Rze	involves: 129P2/OlaHsd * C57BL/6
Pnpla2^tm1Rze/Pnpla2^tm1Rze	involves: 129P2/OlaHsd