Phenotype Image Detail

Image

Caption

Representative EEG recordings from a five-month old wild-type (WT) mouse and an Scn1a^tm1.1Aesc/Scn1a⁺ (Scn1a^RH/+) littermate. A, a normal EEG pattern from an awake WT mouse is shown. B, a normal EEG pattern from a heterozygous mutant is shown. C, an EEG pattern from a heterozygous mutant during an ictal episode. Arrows mark the boundaries of a 32-s polyspike discharge in both hemispheres accompanied by muscle activity, as indicated by the electromyography channel. The seizure was followed by a refractory period. Right EEG, channel recording from right hemisphere. Left EEG, channel recording from left hemisphere; EMG, channel recording from neck muscle.

Copyright

This image is from Martin MS, J Biol Chem 2010 Mar 26;285(13):9823-34 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:161191

Associated Alleles

Symbol	Name
Scn1a^tm1.1Aesc	sodium channel, voltage-gated, type I, alpha; targeted mutation 1.1, Andrew Escayg

Associated Genotypes

Allelic Composition	Genetic Background
Scn1a^tm1.1Aesc/Scn1a^+	involves: 129X1/SvJ * C57BL/6J * SJL