Phenotype Image Detail

Image

Caption

Enhanced destabilization of the medial meniscus (DMM)-induced osteoarthritis cartilage destruction in Cytl1^tm1Chun/Cytl1^tm1Chun mice. A, Wild-type (WT) and Cytl1^tm1Chun/Cytl1^tm1Chun (KO) mice were subjected to a sham operation (control) or destabilization of the medial meniscus (DMM) surgery to induce osteoarthritis (OA) cartilage destruction. Articular cartilage was stained with Safranin-O. The images at right are enlarged versions of the marked region in the left images. Scale bar: 400um. B, Mankin score in WT and KO mice after sham operations and DMM surgery. Values represent means +/-S.E. (n = 16). C, immunohistochemical staining of Col2a1 and Prg4 in joint articular cartilage of WT and KO mice after sham operation and DMM surgery. Scale bar: 400um. D, Safranin-O staining (left) and Makin score (right) of 10-month-old WT and KO mice joint articular cartilage. Scale bar: 400um. Values represent means +/- S.E. (n = 6). *, p<0.05.

Copyright

This image is from Jeon J, J Biol Chem 2011 Aug 5;286(31):27206-13 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:175377

Associated Alleles

Symbol	Name
Cytl1^tm1Chun	cytokine-like 1; targeted mutation 1, Jang-Soo Chun

Associated Genotypes

Allelic Composition	Genetic Background
Cytl1^tm1Chun/Cytl1^tm1Chun	involves: 129S4/SvJae * C57BL/6