Phenotype Image Detail

Image

Caption

Sections through the cornea of Slc4a11^tm1Boet/Slc4a11^tm1Boet (Slc4a11-KO) (D) and wild-type (WT) mice (E) clearly reveal a significant thickening of the corneal stroma with disturbance of the stratification of the epithelium. Electron microscopy sections reveal a thickened Descement membrane and enlarged endothelial cells in Slc4a11^tm1Boet/Slc4a11^tm1Boet mice (F) compared with WT mice (G). Note intracellular vacuolation (arrows in F) in the endothelial cells of KO animals. d, Descement's membrane; e, epithelium; en, endothelium; st, stroma. Scale bars used are as follows: D and E, 50 um; F and G, 2 um.

Copyright

This image is from Groger N, J Biol Chem 2010 May 7;285(19):14467-74 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:162968

Associated Alleles

Symbol	Name
Slc4a11^tm1Boet	solute carrier family 4, sodium bicarbonate transporter-like, member 11; targeted mutation 1, Thomas Boettger

Associated Genotypes

Allelic Composition	Genetic Background
Slc4a11^tm1Boet/Slc4a11^tm1Boet	involves: 129 * C57BL/6