Phenotype Image Detail

Image

Caption

A and B, affected turbinates in castrated Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex} male mice placed on regular mouse pellets (ascorbate (ASC) = 0) for 4 months are shown. Panel A is an hematoxylin and eosin-stained section showing fragments of trabecular bone and a prominent proliferation of dysplastic cell masses filling and distorting the turbinate structure. Panel B shows a section immunostained with RUNX2 antibody, which demonstrates ribbons of committed dysplastic osteoblasts.

Copyright

This image is from Gabbay KH, J Biol Chem 2010 Jun 18;285(25):19510-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:164548

Associated Alleles

Symbol	Name
Akr1a1^Gt(OST222400)Lex	aldo-keto reductase family 1, member A1; gene trap OST222400, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Akr1a1^Gt(OST222400)Lex/Akr1a1^Gt(OST222400)Lex	B6.129S5-Akr1a1^Gt(OST222400)Lex