Phenotype Image Detail

Image

Caption

CAT scans (100 um) showing the "rachitic rosary" (arrows) in a male Gulo^tm1Mae/Gulo^tm1Mae (GULOKO GULO-/-) and an Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex} (AR/GRKO; AR-/-/GR-/-) double knockout (60 days of age). The ball-like swellings at the costochondral junctions of the ribs (arrows) are only seen in these animals and result from hemorrhage and callus formation due to profound ascorbate deficiency The knees and distal tibia are also "swollen". The wild-type (WT) littermate is larger and the rib ends are smooth.

Copyright

This image is from Gabbay KH, J Biol Chem 2010 Jun 18;285(25):19510-20 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:164548

Associated Alleles

Symbol	Name
Akr1a1^Gt(OST222400)Lex	aldo-keto reductase family 1, member A1; gene trap OST222400, Lexicon Genetics
Akr1b1^tm1.1Kgab	aldo-keto reductase family 1 member B; targeted mutation 1.1, Kenneth H Gabbay
Gulo^tm1Mae	gulonolactone (L-) oxidase; targeted mutation 1, Nobuyo Maeda

Associated Genotypes

Allelic Composition	Genetic Background
Akr1a1^Gt(OST222400)Lex/Akr1a1^Gt(OST222400)Lex Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab	B6.Cg-Akr1a1^Gt(OST222400)Lex Akr1b1^tm1.1Kgab
Gulo^tm1Mae/Gulo^tm1Mae	involves: C57BL/6