Phenotype Image Detail

Image

Caption

Whole embryos at E9.5 were stained with anti-CD31 to visualize endothelial cells (ECs). Comparisons are between wild-type (FAK^WT/WT) and Ptk2^tm1.1Itl/Ptk2^tm1.1Itl (FAK^R454/R454) littermates. Defined EC branchlike and tubule structures (arrows) in the head and heart of wild-type embryos are shown. Mutant embryos exhibit intense EC staining in the unfused allantois. Clusters (arrowheads) of ECs are present in mutant head and heart structures, but these were not organized within a defined network.

This image is from Lim ST, J Biol Chem 2010 Jul 9;285(28):21526-36 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165360

Associated
Alleles

Symbol	Name
Ptk2^tm1.1Itl	PTK2 protein tyrosine kinase 2; targeted mutation 1.1, inGenious Targeting Laboratory

Associated
Genotypes

Allelic Composition	Genetic Background
Ptk2^tm1.1Itl/Ptk2^tm1.1Itl	involves: 129S/SvEv * C57BL/6 * SJL

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