Phenotype Image Detail

Image

Caption

A, aortic root morphology was evaluated in wild-type (+/+) and Fbn1^tm1.2Lysa/Fbn1⁺ (GT-8) littermates at various time points. At 2 months of age, breaks in the elastic lamellae could easily be found in heterozygous mice (arrows). These breaks in the elastic lamellae became more severe by 3 months of age in heterozygous mice. By 9 months of age, breaks in the heterozygous lamellae could be found across whole planes of the aortic wall, resulting in infiltration of blood cells (*) into the smooth muscle media. Scale bars = 100um.

Copyright

This image is from Charbonneau NL, J Biol Chem 2010 Aug 6;285(32):24943-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165897

Associated Alleles

Symbol	Name
Fbn1^tm1.2Lysa	fibrillin 1; targeted mutation 1.2, Lynn Y Sakai

Associated Genotypes

Allelic Composition	Genetic Background
Fbn1^tm1.2Lysa/Fbn1^+	involves: C57BL/6