Phenotype Image Detail

Image

Caption

Lack of FGF20 results in undifferentiated lateral compartment cells. (A) Co-immunostaining of E-Cadherin (Cdh1) and Myo6 showing that E-Cadherin stains lateral compartment cells in Fgf20^tm1.1Dor/Fgf20⁺ (Fgf20^betaGal/+) cochlea (A, upper). In homozygous Fgf20^tm1.1Dor/Fgf20^tm1.1Dor (Fgf20^{betaGal/betaGal}) cochlea, E-Cadherin stains all lateral compartment cells including cells localized in the region between sensory patches (A, lower, arrow). (B) Co-immunostaining of Sox2 and phalloidin showing that Sox2 labels supporting cells in heterozygous cochlea (B, upper). In homozygous cochlea, the region between patches was marked by strong Sox2 staining (B, lower arrows). (C) Co-immunostaining of p27 and phalloidin showing that p27 stains supporting cells in heterozygous cochlea (C, upper). In homozygous cochlea, the region between patches was marked by strong p27 staining (C, lower, arrows).

Copyright

This image is from Huh SH, PLoS Biol 2012 Jan;10(1):e1001231, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:184501

Associated Alleles

Symbol	Name
Fgf20^tm1.1Dor	fibroblast growth factor 20; targeted mutation 1.1, David M Ornitz

Associated Genotypes

Allelic Composition	Genetic Background
Fgf20^tm1.1Dor/Fgf20^tm1.1Dor	involves: 129X1/SvJ * C57BL/6J