Phenotype Image Detail

Image

Caption

Gastric pathology of A4gnt^tm1Jnaka/A4gnt^tm1Jnaka mice. (A) Gross appearance of the stomach isolated from wild-type (+/+) and A4gnt^tm1Jnaka/A4gnt^tm1Jnaka (-/-) mice. Scale bar: 5 mm. (B) H&E staining. Low-power view of histology of gastroduodenal mucosa of wild-type and mutant mice, where c, a, and d indicate the gastric corpus, gastric antrum, and duodenum, respectively. Scale bar: 1 mm. (C) Comparison of mucosal thickness of the pyloric mucosa between wild-type and mutant mice at different ages. Each group consists of 6 mice, and data represent the mean +/- SEM. **P < 0.01. (D) Comparison of epithelial cell number in the pyloric mucosa of wild-type and mutant mice at different ages. Each group consists of 6 mice, and data represent the mean +/- SEM. **P < 0.01. (E) Histology of hyperplasia (at 5 weeks), low-grade dysplasia (at 10 weeks), high-grade dysplasia (at 20 weeks), and differentiated type of adenocarcinoma (at 40 weeks, 50 weeks, and 60 weeks) seen in the pyloric mucosa of mutant mice as well as normal pyloric mucosa of 5-week-old wild-type mice. For adenocarcinoma, the desmoplastic reaction in 40-week-old mice, cribriform glands in 50-week-old mice, and irregularly oriented tubular glands in 60-week-old mice are shown. Scale bar: 100 um. Boxed areas are enlarged in lower panels. Scale bar: 50 um.

Copyright

This image is from Karasawa F, J Clin Invest 2012 Mar 1;122(3):923-34 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:184485

Associated Alleles

Symbol	Name
A4gnt^tm1Jnaka	alpha-1,4-N-acetylglucosaminyltransferase; targeted mutation 1, Jun Nakayama

Associated Genotypes

Allelic Composition	Genetic Background
A4gnt^tm1Jnaka/A4gnt^tm1Jnaka	B6.129S6-A4gnt^tm1Jnaka