Phenotype Image Detail

Image

Caption

A subset of Myl2^tm2.1Chen/Myl2^tm2.1Chen mice (DMs) sporadically display cardiac calcification and fibrosis with a modest re-expression of the fetal cardiac marker, Beta-MHC. (A, far left) Gross morphology of wild-type (WT) and mutant mouse hearts at three months of age. Bar is equivalent to 2 mm. (A, middle left) Cardiac sections from WT and mutant mice were stained with the von Kossa stain. Bar is equivalent to 2 mm. Red square highlights calcification in ventricular septum endocardium of mutant mouse heart. (A, right) High magnification view of calcification (top, middle) and fibrosis (top, right) in ventricular septum endocardium of mutant mouse heart (DMs-Se). Right atrium stained with von Kossa stain (DMs-RA) displays calcification in this region. Masson Trichrome stain of left atrium (LA) and ventricle (LV) in mutant mice reveal fibrosis in these regions. Bar is equivalent to 150 um.

Copyright

This image is from Sheikh F, J Clin Invest 2012 Apr 2;122(4):1209-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:184548

Associated Alleles

Symbol	Name
Myl2^tm2.1Chen	myosin, light polypeptide 2, regulatory, cardiac, slow; targeted mutation 2.1, Ju Chen

Associated Genotypes

Allelic Composition	Genetic Background
Myl2^tm2.1Chen/Myl2^tm2.1Chen	B6.129-Myl2^tm2.1Chen