Phenotype Image Detail

Image

Caption

Bone defects in the 6-week-old Fam20c^tm1.1Cqi/Fam20c^tm1.1Cqi Edil3^{Tg(Sox2-cre)1Amc}/0 mice revealed by X-ray and histology. (B) Plain X-ray of the tail of mutant mice (left) showed hypomineralization; shorter length, and underdeveloped secondary ossification centers (arrowheads), compared with the wild-type (WT) littermates (right). (C,D) Micro-CT analyses. The tibia of the mutant mice (left) showed shorter length, thinner cortical bone (arrow), more porous areas on both the outer and inner surfaces (indicating more hypomineralized areas) and smaller secondary ossification centers (arrowheads), compared with their WT littermates (right). Scale bars: 1 mm in B-D.

Copyright

This image is from Wang X, PLoS Genet 2012 May;8(5):e1002708, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185208

Associated Alleles

Symbol	Name
Edil3^Tg(Sox2-cre)1Amc	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Fam20c^tm1.1Cqi	FAM20C, golgi associated secretory pathway kinase; targeted mutation 1.1, Chunlin Qin

Associated Genotypes

Allelic Composition	Genetic Background
Fam20c^tm1.1Cqi/Fam20c^tm1.1Cqi Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S6/SvEvTac * C57BL/6 * CBA