Phenotype Image Detail

Image

Caption

Rgs7^tm1Cjch/Rgs7^tm1Cjch Rgs11^tm1Lex/Rgs11^tm1Lex double knock-out (DKO) mice have no electroretinogram (ERG) b-waves and contain ultrastructural defects in the retinal outer plexiform layer (OPL). A, representative scotopic ERG responses from 2-month-old wild-type control and double knock-out (DKO) mice with flash intensity indicated at left in units of log cd sm^-2. B, immunohistochemical staining of control and mutant retinal sections for CtBP2 (1:2,000, white) and PKCalpha (1:100,000, red) demonstrating reduction in rod bipolar cell dendritic arborization. BV, blood vessel. Scale bar, 5 um. C, representative transmission electron microscopic images of the OPL from control and mutant mice. Scale bar, 2 um. RS, rod spherule. Asterisk denotes abnormal structure. D and E, percentage of rod spherules with normal synaptic triads (D) and ribbons (E) in the mutant (n=4, 80 images) versus control (n=3, 65 images) retinas (*, p< 0.01). Error bars are S.D.

Copyright

This image is from Shim H, J Biol Chem 2012 Apr 27;287(18):14873-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:184922

Associated Alleles

Symbol	Name
Rgs11^tm1Lex	regulator of G-protein signaling 11; targeted mutation 1, Lexicon Genetics
Rgs7^tm1Cjch	regulator of G protein signaling 7; targeted mutation 1, Ching-Kang Chen

Associated Genotypes

Allelic Composition	Genetic Background
Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1Cjch/Rgs7^tm1Cjch	involves: 129S5/SvEvBrd * C57BL/6