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Caption | Bmi1 cooperates with Pten haploinsufficiency in prostate cancer progression. (D-G) H&E stained prostate sections. (D) Normal epithelium in Tg(Pbsn-cre)4Prb/0 (PbCre4) controls. (E) Prostatic intraepithelial neoplasia (PIN) lesion (asterisk) in Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+ (PbCre4;Bmi1LSL) mice. (F) PIN lesion (asterisk) in Tg(Pbsn-cre)4Prb/0 Ptentm1Mro/Pten+ (PbCre4;PtenloxP/+) mice. (G) Adenocarcinoma in Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sortm1(CAG-Bmi1,-EGFP)Nki/Gt(ROSA)26Sor+ Ptentm1Mro/Pten+ (PbCre4;Bmi1LSL;PtenloxP/+) animals. Black arrowhead, mitotic figure; white arrowheads, blood vessels. Insets are enlarged 5-fold. (H-O) Immunohistochemical expression analysis of Bmi1-phosphorylated Akt (H-K) and pAkt (S473) (L-O). Scale bars: 100 um. | ||||||||
Copyright | This image is from Nacerddine K, J Clin Invest 2012 May 1;122(5):1920-32 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:184533 | ||||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/24/2024 MGI 6.24 |
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