Phenotype Image Detail

Image

Caption

(C-K) Representative histopathology of tumors from Pik3ca^tm1.1Waph/Pik3ca^tm1.1Waph Pten^tm1Hwu/Pten^tm1Hwu (Pik3ca^H1047RPten^del/del) mice. Non-AdCre-exposed ovary (C), serous adenocarcinoma (D-H), and granulosa cell tumor (I-K). Staining with H&E (C-E, I, and J), p-Akt S473 (F, high-power inset), p-Rps6 (G, high power inset), pankeratin (H, adjacent uterus inset), or inhibin (K) is shown. Scale bars: bracketed, 500 mm; unbracketed, 50 mm. B, bursa; CL, corpus luteum; F, follicle; FP, fat pad.

Copyright

This image is from Kinross KM, J Clin Invest 2012 Feb 1;122(2):553-7 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:184382

Associated Alleles

Symbol	Name
Pik3ca^tm1.1Waph	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1.1, Wayne A Phillips
Pten^tm1Hwu	phosphatase and tensin homolog; targeted mutation 1, Hong Wu

Associated Genotypes

Allelic Composition	Genetic Background
Pik3ca^tm1.1Waph/Pik3ca^+ Pten^tm1Hwu/Pten^tm1Hwu	involves: 129S1/Sv * 129S4/SvJae * BALB/c * C57BL/6