Phenotype Image Detail

Image

Caption

Livers of Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice conatin fewer hepatocytes. (A) Liver sections from Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 (Cdk1^Liv-/-) and control (Cdk1^FLOX) mice were stained with Feulgen to visualize their nuclei. Even though the overall liver size (B) is similar, mutant livers contained fewer hepatocytes with enlarged nuclei. (G) Mutants display a decreased hepatocyte density compared with controls and the difference is exacerbated by 96 hours after partial hepatectomy.

Copyright

This image is from Diril MK, Proc Natl Acad Sci U S A 2012 Mar 6;109(10):3826-31. Copyright 2012 National Academy of Sciences, U.S.A. J:182141

Associated Alleles

Symbol	Name
Cdk1^tm2.1Kald	cyclin dependent kinase 1; targeted mutation 2.1, Philipp Kaldis
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated Genotypes

Allelic Composition	Genetic Background
Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129 * C57BL/6 * DBA * SJL