Phenotype Image Detail

Image

Caption

Loss of pancreatic beta-cells in aged Huwe1^tm1Wgu/Y Tg(Ins2-cre)23Herr/0 mice. B, immunostaining of pancreases from the control (i-vi) and from the Huwe1^tm1Wgu/Y Tg(Ins2-cre)23Herr/0 (arf-bp1^FL/Y/RIP-cre) mice (vii-xii). i, iv, vii, and x, 1 month old mice; ii, v, viii, and xi, 6 month old mice; and iii, vi, ix, and xii, 9 month old mice. Antibodies against insulin (i-iii and vii-ix) and glucagon (iv-vi and x-xii) were used. Dotted circles in ix outline the islets.

Copyright

This image is from Kon N, J Biol Chem 2012 Feb 10;287(7):5102-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:182446

Associated Alleles

Symbol	Name
Huwe1^tm1Wgu	HECT, UBA and WWE domain containing 1; targeted mutation 1, Wei Gu
Tg(Ins2-cre)23Herr	transgene insertion 23, Pedro Luis Herrera

Associated Genotypes

Allelic Composition	Genetic Background
Huwe1^tm1Wgu/Y Tg(Ins2-cre)23Herr/0	involves: C57BL/6J * CBA/J