Phenotype Image Detail

Image

Caption

(F) Electron micrographic images of livers from fed and 24 hour fasted Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} (f/f;Alb-Cre^-: controls) and Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 (f/f:Alb-Cre⁺: mutant) mice. Higher magnification views of boxed areas are numbered and shown in Lower. Gly, glycogen area; arrowheads point to autophagosomes; asterisks denote lipid droplets. Note the lack of glycogen deposition, accumulation of lipid droplets, and smaller mitochondria in fed mutant livers. Starved mutant livers are devoid of autophagosomes but are noted to have swollen mitochondria.

Copyright

This image is from Jaber N, Proc Natl Acad Sci U S A 2012 Feb 7;109(6):2003-8. Copyright 2012 National Academy of Sciences, U.S.A. J:182628

Associated Alleles

Symbol	Name
Pik3c3^tm1c(EUCOMM)Wtsi	phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1c, Wellcome Trust Sanger Institute
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated Genotypes

Allelic Composition	Genetic Background
Pik3c3^tm1c(EUCOMM)Wtsi/Pik3c3^tm1c(EUCOMM)Wtsi Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: C57BL/6 * C57BL/6N * DBA