Phenotype Image Detail

Image

Caption

Cardiac dysfunction in Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(Ckmm-cre)5Khn/0 mice. (A) Hearts isolated from 6-week-old Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} (f/f;Mck-Cre^-: control) and Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(Ckmm-cre)5Khn/0 (f/f;Mck-Cre⁺: mutant) mice were photographed. (B) Hearts were weighed, and the heart mass is normalized to body mass. (C) Representative B-mode (left ventricle labeled) and M-mode echocardiographic images of control and mutant mice. (D) Kaplan-Meier survival curve of control and mutant mice. (E) Representative EM images of control and mutant hearts. Note that wild-type heart section shows characteristic alignment of mitochondria and organization of Z-lines, whereas the mutant tissue shows disorganized mitochondria and Z-lines.

Copyright

This image is from Jaber N, Proc Natl Acad Sci U S A 2012 Feb 7;109(6):2003-8. Copyright 2012 National Academy of Sciences, U.S.A. J:182628

Associated Alleles

Symbol	Name
Pik3c3^tm1c(EUCOMM)Wtsi	phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1c, Wellcome Trust Sanger Institute
Tg(Ckmm-cre)5Khn	transgene insertion 5, C Ronald Kahn

Associated Genotypes

Allelic Composition	Genetic Background
Pik3c3^tm1c(EUCOMM)Wtsi/Pik3c3^tm1c(EUCOMM)Wtsi Tg(Ckmm-cre)5Khn/0	involves: C57BL/6N * FVB/N