Phenotype Image Detail

Image

Caption

Neuropathology of Arsg^tm1Tdi/Arsg^tm1Tdi (Arsg KO) mice. (A) Perivascular macrophages from the cerebral cortex show similar vacuolization as seen in the cerebellum. (B) Transmission electron microscopy (TEM) of a macrophage from the pia mater reveals mostly empty vacuoles, suggesting water-soluble contents and some with electron-dense material. (C and D) Toluidine blue-stained Epon-embedded sections of the CNS reveal sporadic storage vacuoles (arrows) in thalamic (C) and hippocampal (D) neurons (CA3 region), comparable to the observations in Purkinje cells. (E and E') Autofluorescence was detected in the molecular layer of the cerebellum of knockout animals with different filter settings (GFP, Y3, and BGR).

Copyright

This image is from Kowalewski B, Proc Natl Acad Sci U S A 2012 Jun 26;109(26):10310-5. Copyright 2012 National Academy of Sciences, U.S.A. J:185592

Associated Alleles

Symbol	Name
Arsg^tm1Tdi	arylsulfatase G; targeted mutation 1, Thomas Dierks

Associated Genotypes

Allelic Composition	Genetic Background
Arsg^tm1Tdi/Arsg^tm1Tdi	involves: 129S2/SvPas * C57BL/6