Phenotype Image Detail

Image

Caption

Disrupted formation of parallel fibers in Trio^tm1Mzhu/Trio^tm1Mzhu Tg(Nes-cre)1Kln/0 mice (Trio^NKO). A and B, early parallel fibers in the inner external granule cell layer (EGL) labeled with TAG-1 are thick and non-compact in Trio-deficient mice compared with control littermates. C and D, hematoxylin and eosin stained of coronal sections of P0.5 cerebella. Spindle-shaped cells (arrowheads) are horizontally located in the inner EGL of control mice. Mutant cell bodies in the inner EGL are disordered. E and F, DiI-labeled parallel fibers. Horizontal beams of parallel fibers in the inner EGL of CTR cerebellum (E) are not formed in the Trio mutant (F). Disorganized fibers are indicated by white arrowheads. Dashed lines indicate the pial surface of the cerebella. Scale bars in A-F: 20 um.

Copyright

This image is from Peng YJ, J Biol Chem 2010 Aug 6;285(32):24834-44 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165902

Associated Alleles

Symbol	Name
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein
Trio^tm1Mzhu	triple functional domain (PTPRF interacting); targeted mutation 1, Min-Sheng Zhu

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Nes-cre)1Kln/0 Trio^tm1Mzhu/Trio^tm1Mzhu	involves: 129S6/SvEvTac * C57BL/6 * SJL