Phenotype Image Detail

Image

Caption

Abnormal neurite morphogenesis of Trio^tm1Mzhu/Trio^tm1Mzhu Tg(Nes-cre)1Kln/0 (Trio^NKO) cerebellar granule cells in culture. A, representative granule cells 2.5 days after plating. Neurons were double-labeled with antibody against Tuji1 and TRITC-labeled phalloidin. White arrowheads indicate mutant axon branches. I', II', and III' are magnifications of I, II, and III, respectively, emphasizing irregular growth cone formation in the mutant.

Copyright

This image is from Peng YJ, J Biol Chem 2010 Aug 6;285(32):24834-44 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165902

Associated Alleles

Symbol	Name
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein
Trio^tm1Mzhu	triple functional domain (PTPRF interacting); targeted mutation 1, Min-Sheng Zhu

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Nes-cre)1Kln/0 Trio^tm1Mzhu/Trio^tm1Mzhu	involves: 129S6/SvEvTac * C57BL/6 * SJL