Phenotype Image Detail

Image

Caption

Histological analysis of newborn Tg(Prrx1-cre)1Cjt/0 (Prx1-Cre/Vcan+/+; control) (A,C) and Vcan^tm1.1Hwat/Vcan^tm1.1Hwat Tg(Prrx1-cre)1Cjt/0 (Prx1-Cre/Vcan^flox/flox; mutant) (B,D) forelimbs by H&E staining. Mutant digits display joint tilting (arrowhead in B), and formation of hypertrophic chondrocyte nodule in proximal phalanges and delayed endochondral ossification (D). M, metacarpus; pp, proximal phalanges. Scale bars: (A,B) 100 um; (C,D) 25 um.

Copyright

This image is from Choocheep K, J Biol Chem 2010 Jul 2;285(27):21114-25 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165936

Associated Alleles

Symbol	Name
Tg(Prrx1-cre)1Cjt	transgene insertion 1, Clifford J Tabin
Vcan^tm1.1Hwat	versican; targeted mutation 1.1, Hideto Watanabe

Associated Genotypes

Allelic Composition	Genetic Background
Vcan^tm1.1Hwat/Vcan^tm1.1Hwat Tg(Prrx1-cre)1Cjt/0	involves: C57BL/6 * C57BL/6J * SJL/J