Phenotype Image Detail

Image

Caption

D, quantification of plaque load in the cortex and hippocampus of App^tm3.1Zhe/App^tm3.1Zhe Psen1^tm1Mpm/Psen1^tm1Mpm (APP/hAbeta/mutC PS1 M146V/M146V), App^tm3.1Zhe/App^tm3.1Zhe Psen1^tm1Mpm/App⁺ (APP/hAbeta/mutC PS1 M146V/+), and App^tm1Ck/App^tm1Ck Psen1^tm1Mpm/Psen1^tm1Mpm (APP/hAbeta PS1 M146V/M146V) mice. ***, p < 0.001; N.S., non-significant (analysis of variance).

Copyright

This image is from Li H, J Biol Chem 2010 Oct 1;285(40):30598-605 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166379

Associated Alleles

Symbol	Name
App^tm3.1Zhe	amyloid beta precursor protein; targeted mutation 3.1, Hui Zheng
Psen1^tm1Mpm	presenilin 1; targeted mutation 1, Mark P Mattson

Associated Genotypes

Allelic Composition	Genetic Background
App^tm3.1Zhe/App^tm3.1Zhe Psen1^tm1Mpm/Psen1^tm1Mpm	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6