Phenotype Image Detail

Image

Caption

Experimental osteolysis. A, illustrative x-ray radiographs of parietal bones from wild-type (WT) and Fbn2^tm1Rmz/Fbn2^tm1Rmz (Fbn2-/-) mice that were sham-operated (top; -Ti) or implanted with LPS-titanium beads (bottom; + Ti) (n = 3 per each genotype and treatment). Resorption areas (orange) in each parietal bone were delineated in a blinded fashion from the x-ray radiographs using NIH Image-based histomorphometry. B, representative images of TRAP-stained parietal bones (scale bar = 100um) that were sectioned along the white dotted line shown in the x-ray images of panel A; below are magnified images (20X) of the boxed areas above with arrows pointing to TRAP-positive cells.

Copyright

This image is from Nistala H, J Biol Chem 2010 Oct 29;285(44):34126-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166786

Associated Alleles

Symbol	Name
Fbn2^tm1Rmz	fibrillin 2; targeted mutation 1, Francesco Ramirez

Associated Genotypes

Allelic Composition	Genetic Background
Fbn2^tm1Rmz/Fbn2^tm1Rmz	involves: 129S/SvEv