Phenotype Image Detail

Image

Caption

A, depth profile of hippocampal tissue through three consecutive sections of 14-month-old Tg(PRNP-APPSweInd)8Dwst/0 (TgCRND8) mouse brain. Fourier transform infrared Focal plane array (FTIR-FPA) maps were processed for band area of CH2 symmetric stretch to show tissue morphology (gray scale below). Creatine locations from map processed on a creatine band area at 1400 cm^-1 are overlaid (color gradient below). Scale bar, 100 um. B, synchrotron FTIR (sFTIR) analysis of dense core plaque from 17-month-old mutant mouse. a, light microscope image. b-d, sFTIR map was processed for: Beta-sheet in amide 1 region (b), creatine band at 1400 cm^-1 (c), and lipid membrane from band area of CH2 symmetric stretch (d). Scale bar, 50 um.

Copyright

This image is from Kuzyk A, J Biol Chem 2010 Oct 8;285(41):31202-7 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166801

Associated Alleles

Symbol	Name
Tg(PRNP-APPSweInd)8Dwst	transgene insertion 8, David Westaway

Associated Genotypes

Allelic Composition	Genetic Background
Tg(PRNP-APPSweInd)8Dwst/0	involves: C3H/HeJ * C57BL/6J