Phenotype Image Detail

Image

Caption

D shows islet immunohistochemistry, and islets from wild-type (hadh+/+; a and b) and Hadh^tm1Csta/Hadh^tm1Csta (hadh-/-; c and d) are shown. Insulin is stained green, glucagon is red, and nuclear is blue. Glucagon-staining alpha-cells are distributed throughout the islet in mutants, rather than being restricted to the outer margin as in wild-type mice.

Copyright

This image is from Li C, J Biol Chem 2010 Oct 8;285(41):31806-18 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166803

Associated Alleles

Symbol	Name
Hadh^tm1Csta	hydroxyacyl-Coenzyme A dehydrogenase; targeted mutation 1, Charles A Stanley

Associated Genotypes

Allelic Composition	Genetic Background
Hadh^tm1Csta/Hadh^tm1Csta	involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss