Phenotype Image Detail

Image

Caption

Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 (Aip^fx/fxCre) mice are resistant to dioxin-induced hepatic damage. Mice were treated with corn oil or 64 ug/kg of dioxin and sacrificed 5 days after the single i.p. injection. The liver sections were stained with hematoxylin and eosin. Magnification, x100. Black arrowhead, the region of hydropic degeneration; asterisk, focal inflammation.

Copyright

This image is from Nukaya M, J Biol Chem 2010 Nov 12;285(46):35599-605 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166864

Associated Alleles

Symbol	Name
Ahr^b-1	aryl-hydrocarbon receptor; b-1 variant
Aip^tm2.1Bra	aryl-hydrocarbon receptor-interacting protein; targeted mutation 2.1, Christopher A Bradfield
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated Genotypes

Allelic Composition	Genetic Background
Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	B6.Cg-Speer6-ps1^Tg(Alb-cre)21Mgn Aip^tm2.1Bra