Phenotype Image Detail

Image

Caption

Impact of hepatocyte Aip deletion on dioxin-induced hepatotoxicity. Mice were treated with corn-oil alone or 64 ug/kg of dioxin in corn-oil, and sacrificed five days after the single injection. The liver sections were stained with H&E for assessment of dioxin-induced hepatotoxicity (Magnification; x100): Black arrowhead; the region of hydropic degenerations, *; focal inflammation. (A) Control (Aip^fx/fx) given corn-oil, (B) control given dioxin, (C) Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 (Aip^fx/fxCre^alb) given corn-oil, (D) Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 given dioxin. The liver sections were obtained from different individual mice (samples (i)-(iii)).

Copyright

This image is from Nukaya M, J Biol Chem 2010 Nov 12;285(46):35599-605 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166864

Associated Alleles

Symbol	Name
Ahr^b-1	aryl-hydrocarbon receptor; b-1 variant
Aip^tm2.1Bra	aryl-hydrocarbon receptor-interacting protein; targeted mutation 2.1, Christopher A Bradfield
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated Genotypes

Allelic Composition	Genetic Background
Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	B6.Cg-Speer6-ps1^Tg(Alb-cre)21Mgn Aip^tm2.1Bra