Phenotype Image Detail

Image

Caption

Antral hyperplasia in Spdef^tm1Shiv/Spdef^tm1Shiv mice. The spectrum of hyperplastic changes in mutant antra includes focal cyst formation (A, arrow) and tubular to cribriform growth patterns (B), with broad extension of the epithelial proliferative zone, as indicated by Ki67 immunostaining (C). Inset in C shows a higher magnification of the boxed area. Immunostaining for the intestinal marker Cdx2 (D), the chief cell product gastric intrinsic factor (E), and the parietal cell marker Atp4b (F) demonstrate absence of heterotopia or metaplasia in the mutant hyperplastic antrum. Insets show positive staining controls. Scale bars, 250 um.

Copyright

This image is from Horst D, J Biol Chem 2010 Nov 5;285(45):35047-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:166876

Associated Alleles

Symbol	Name
Spdef^tm1Shiv	SAM pointed domain containing ets transcription factor; targeted mutation 1, Ramesh Shivdasani

Associated Genotypes

Allelic Composition	Genetic Background
Spdef^tm1Shiv/Spdef^tm1Shiv	involves: 129S4/SvJae