Phenotype Image Detail

Image

Caption

Phenotypic analysis of Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd mice. C-D. H&E skin sections of mutant (C) and wild-type control (D) mice at P20. Arrow in (D) points to subcutaneous fat. E. X-ray image of wild-type (upper) and mutant (lower) mice at P28. Mutant mice have reduced bone density compared with control mice (arrows).

Copyright

This image is from Xiao C, J Biol Chem 2010 Nov 19;285(47):36776-84 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167023

Associated Alleles

Symbol	Name
Sirt6^tm2.2Cxd	sirtuin 6; targeted mutation 2.2, Chu-Xia Deng

Associated Genotypes

Allelic Composition	Genetic Background
Sirt6^tm2.2Cxd/Sirt6^tm2.2Cxd	involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss