Phenotype Image Detail

Image

Caption

Increased neurodegeneration in Atmin^tm1Axbe/Atmin^tm1Axbe Tg(Nes-cre)1Kln/0 brains. A, H&E stain of coronal sections through the midbrain of 18-month-old control (ATMIN^F/F) and Atmin^tm1Axbe/Atmin^tm1Axbe Tg(Nes-cre)1Kln/0 (ATMIN^deltaN) mice showing similar morphology. B, sections from 2- and 18-month-old control and mutant mice were stained with NeuN to quantify neuronal density. The percentage loss in neuronal density through the cortex of control and mutant mice was calculated. C, sections from 18-month-old mice were stained with anti-glial fibrillary acidic protein antibody to measure astrocytic gliosis and with anti-Iba1 antibody for activated microglia (D). All numbers were corrected using the Abercrombie method. The histograms represent the quantification of staining from three mice.

Copyright

This image is from Kanu N, J Biol Chem 2010 Dec 3;285(49):38534-42 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167331

Associated Alleles

Symbol	Name
Atmin^tm1Axbe	ATM interactor; targeted mutation 1, Axel Behrens
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Atmin^tm1Axbe/Atmin^tm1Axbe Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL