Phenotype Image Detail

Image

Caption

Ticam1 deficiency confers protective effects against dextran sulfate sodium (DSS)-induced colitis and flagellin-mediated exacerbation of DSS-induced colitis. Flagellin-exacerbated DSS-induced colitis was relieved in Ticam1^Lps2/Ticam1^Lps2 (TRIF-KO) mice compared with wild-type (WT) mice. Mutant (n = 14) and WT (n = 21) mice were fed with DSS (3%) for total 9 days, and mice were treated with flagellin enema (0.8 - 1.0 ug/mouse/day) during the last 5 days. B, representative H&E-stained mid- and proximal colon tissues were prepared from flagellin-exacerbated DSS-induced colitis of mutant and WT mice. Scale bars, 100 um.

Copyright

This image is from Choi YJ, J Biol Chem 2010 Nov 26;285(48):37570-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167340

Associated Alleles

Symbol	Name
Ticam1^Lps2	TIR domain containing adaptor molecule 1; lipopolysaccharide 2

Associated Genotypes

Allelic Composition	Genetic Background
Ticam1^Lps2/Ticam1^Lps2	C57BL/6J-Ticam1^Lps2