Phenotype Image Detail

Image

Caption

Auditory hair cell planar polarity phenotypes are enhanced in the Vangl2^tm1.2Mdea/Vangl2^Lp (vangl2^deltaTMs/Lp) cochlea relative to Vangl2^tm1.2Mdea/Vangl2^tm1.2Mdea (vangl2^{deltaTMs/deltaTMs}). (A) Confocal image of auditory hair cells from an E18.5 wild-type mouse in which hair cells are labeled for phalloidin (green) and pericentrin (red). (A') Schematic illustrating the orientation of stereocilia bundles from each of the hair cells present in panel (A). (B-C) Confocal images and corresponding orientation schematics from Vangl2^tm1.2Mdea/Vangl2^tm1.2Mdea (B, B') and Vangl2^tm1.2Mdea/Vangl2^Lp cochleae (C, C'). All images were collected from a basal position corresponding to 25% of the length of the cochlea as measured from the base to the apex. IHC (inner hair cell), OHC1 (outer hair cell 1), OHC2 (outer hair cell 2), OHC3 (outer hair cell 3). Scale bar is 10 um.

Copyright

This image is from Yin H, PLoS One 2012;7(2):e31988, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185311

Associated Alleles

Symbol	Name
Vangl2^Lp	VANGL planar cell polarity 2; loop tail
Vangl2^tm1.2Mdea	VANGL planar cell polarity 2; targeted mutation 1.2, Michael R Deans

Associated Genotypes

Allelic Composition	Genetic Background
Vangl2^Lp/Vangl2^tm1.2Mdea	involves: 129S/Sv * C57BL/6 * FVB/N * LPT/LeJ * SJL
Vangl2^tm1.2Mdea/Vangl2^tm1.2Mdea	B6NCrl.129S6(Cg)-Vangl2^tm1.2Mdea