Phenotype Image Detail

Image

Caption

A) Major cranial anomalies observed in Prkra^rep/Prkra^rep (rep/rep) and Prkra^tm1Gcs/Prkra^tm1Gcs (Prkra^tm1Gsc) mice. Arrows indicate the principal defects for each mutant, i.e. the reduced coronoid process and mandibular condyle, and the short nasal bone in Prkra^rep/Prkra^rep (rep/rep) mice and the bregmatic fontanelle-like structure of Prkra^tm1Gcs/Prkra^tm1Gcs (Prkra^tm1Gsc) mice. Scale bar: 5 mm. B) Plot of principal components 1 and 2 based on Procrustes analysis of 3D landmark coordinates of wild-type (wt), Prkra^rep/Prkra^rep and Prkra^tm1Gcs/Prkra^tm1Gcs mice. Squares: wt mice; Triangles: Prkra^tm1Gcs/Prkra^tm1Gcs mice; Filled diamonds: Prkra^rep/Prkra⁺ heterozygous mice; Open diamonds: Prkra^rep/Prkra^rep homozygous mice. On the principal components analysis (PCA) performed from cranial landmarks (top panel), PC1 represents 54.7% of variance and PC2 15.1%. On the PCA performed from mandibular landmarks (bottom panel), PC1 represents 46.0% of variance and PC2 16.1%

Copyright

This image is from Dickerman BK, PLoS One 2011;6(12):e28537, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185991

Associated Alleles

Symbol	Name
Prkra^rep	protein kinase, interferon inducible double stranded RNA dependent activator; reduced pinna
Prkra^tm1Gcs	protein kinase, interferon inducible double stranded RNA dependent activator; targeted mutation 1, Ganes C Sen

Associated Genotypes

Allelic Composition	Genetic Background
Prkra^rep/Prkra^rep	involves: C3HeB/FeJ * C57BL/6J
Prkra^tm1Gcs/Prkra^tm1Gcs	Not Specified