Phenotype Image Detail

Image

Caption

Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir155)Fjsl}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wmz/0 (mir-155^LSLtTA) mice develop disseminated lymphoma. (A) Mutant mouse with ruffled fur and massively enlarged peripheral and axillary lymph nodes (arrowheads) (n=20). (C, D) Representative H&E sections from wild-type mice reveal distinct periarteriolar lymphocyte sheaths (PALS) in spleen and normal cortex and medullary in thymus; (n=20). (E, F) Representative H&E sections from mutant mouse spleen and thymus. Spleen and thymic parenchyma are effaced and replaced by a monotonous population of lymphoblasts (n=20). (G-J) Lymphocyte infiltration into liver, submandibular lymph nodes (SMLN), meninges of the brain (I, asterisk), paravertebral lymph nodes (J, arrows), and meninges of the spinal cord (J, arrowhead). Scale bars, 500 um (n=20).

Copyright

This image is from Babar IA, Proc Natl Acad Sci U S A 2012 Jun 26;109(26):E1695-704. Copyright 2012 National Academy of Sciences, U.S.A. J:185598

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1(tTA,tetO-Mir155)Fjsl	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frank J Slack
Tg(Nes-cre)1Wmz	transgene insertion 1, Weimin Zhong

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor^+ Tg(Nes-cre)1Wmz/0	involves: 129 * C57BL/6 * FVB/N * SJL/J