Phenotype Image Detail

Image

Caption

Tg(Ly6e-MALT1)#Isg/0 Trp53^tm1Tyj/Trp53^tm1Tyj (Sca1-MALT1,p53-/-) mice develop activated B-cell diffuse large-cell lymphoma (ABC-DLBCL). (B) Macroscopic aspect of the intestine and spleen in double mice vs. wild-type (WT) and Trp53^tm1Tyj/Trp53^tm1Tyj (p53-/-) age-matched mice. (C) Representative hematoxylin-eosin (HE) staining and IHC analysis for CD20, Foxp1, Mum1, Gcet1, CD10, and Bcl6 in double mutant mice. Appropriate positive and negative control tissues for each antibody were used.

Copyright

This image is from Vicente-Duenas C, Proc Natl Acad Sci U S A 2012 Jun 26;109(26):10534-9. Copyright 2012 National Academy of Sciences, U.S.A. J:185590

Associated Alleles

Symbol	Name
Tg(Ly6e-MALT1)#Isg	transgene insertion, Isidro Sanchez-Garcia
Trp53^tm1Tyj	transformation related protein 53; targeted mutation 1, Tyler Jacks

Associated Genotypes

Allelic Composition	Genetic Background
Trp53^tm1Tyj/Trp53^tm1Tyj Tg(Ly6e-MALT1)#Isg/0	involves: 129S2/SvPas * C57BL/6 * CBA