Phenotype Image Detail

Image

Caption

Trophoblast giant cells (TGCs) in wild-type (WT Fem) and heterozygous Plac1^{tm1(KOMP)Vlcg}/Plac1⁺ females that inherit the mutant allele from the mother (X^m-X) and in homozygous Plac1^{tm1(KOMP)Vlcg}/Plac1^{tm1(KOMP)Vlcg} females that inherit one mutant allele from the mother and the other mutant allele from the father (X^m-X^p-). In situ hybridization of Prl2c2 expression using the digoxygenin detection system. Increased TGCs numbers were evident in the labyrinth layer of females inheriting the mutant allele from the mother. Black arrows = partial TGCs adjacent to the decidua; Green arrow = sinusoidal TGCs; Red arrow = spongiotrophoblasts at the interface of the junctional zone and labyrinth. Non-specific signal was determined by hybridization with the "sense" riboprobe construct. Magnification = 1.5x.

Copyright

This image is from Jackman SM, Mol Reprod Dev 2012 Aug;79(8):564-72, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:186550

Associated Alleles

Symbol	Name
Plac1^tm1(KOMP)Vlcg	placental specific protein 1; targeted mutation 1, Velocigene
Plac1^tm1(KOMP)Vlcg	placental specific protein 1; targeted mutation 1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Plac1^tm1(KOMP)Vlcg/Plac1^tm1(KOMP)Vlcg	C57BL/6N-Plac1^tm1(KOMP)Vlcg
Plac1^tm1(KOMP)Vlcg/Plac1^+	C57BL/6N-Plac1^tm1(KOMP)Vlcg