Phenotype Image Detail

Image

Caption

Defective exocrine glands in Sec23b^{Gt(AD0407)Wtsi}/Sec23b^{Gt(AD0407)Wtsi} (Sec23b^gt/gt) mice. (A) H&E staining of submandibular gland, sublingual gland and the fundus of stomach of wild-type (WT) and mutant E18.5 embryos. Arrows denote gastric epithelium and gastric glands in stomach. Degeneration of serous and mucous acini and the gastric glands is evident with the disorganized structures and abundance of unstained intracellular spaces in mutant embryos. (Scale bar: 50 um) (B) EM images of serous acini and mucous acini in salivary glands of WT and mutant E18.5 embryos. Dilated ER structure is observed in both types of acini, with no secretory granules found in mucous acini in mutant E18.5 salivary glands. (Scale bars: lower magnification, 1 um; higher magnification, 0.5 um.)

Copyright

This image is from Tao J, Proc Natl Acad Sci U S A 2012 Jul 17;109(29):E2001-9. Copyright 2012 National Academy of Sciences, U.S.A. J:186391

Associated Alleles

Symbol	Name
Sec23b^Gt(AD0407)Wtsi	SEC23 homolog B, COPII coat complex component; gene trap AD0407, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Sec23b^Gt(AD0407)Wtsi/Sec23b^Gt(AD0407)Wtsi	B6J.129P2-Sec23b^Gt(AD0407)Wtsi