Phenotype Image Detail

Image

Caption

Phenotype of Porcn^tm1.1Vdv/Y Tg(Prrx1-cre)1Cjt/0 (PrxcKO) mice. (A) Shortened forelimbs at E18.5 in mutants compared to wild-type littermate (control). (B) Stunted growth at day 7 (P7) in PrxcKO compared to control littermate. (C) Appearance of PrxcKO compared to WT littermate at P28. (D) Digital abnormalities showing shortened limbs and shortened digits in PrxcKO compared to WT. F, forelimb; H, hindlimb. (E) Whole-skeleton preparations of newborn mice (NB). Mutant exhibits shortening of all skeletal elements. (F, G) Skeletal preparations of NB forelimbs and hindlimbs. (H) Whole-skeleton preparations of P28 mice. Mutant exhibits more dramatic shortening of all skeletal elements. (I, J) Skeletal preparations of forelimbs (F) and hindlimbs (H) at P28. hu, humerus; ra, radius; sc, scapula; ul, ulna; cl, clavicle; il, ilium; pu, pubis; fe, femur; ti, tibia; fi, fibula.

Copyright

This image is from Liu W, PLoS One 2012;7(3):e32331, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:186934

Associated Alleles

Symbol	Name
Porcn^tm1.1Vdv	porcupine O-acyltransferase; targeted mutation 1.1, Ignatia B Van den Veyver
Tg(Prrx1-cre)1Cjt	transgene insertion 1, Clifford J Tabin

Associated Genotypes

Allelic Composition	Genetic Background
Porcn^tm1.1Vdv/Y Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6 * SJL/J