Phenotype Image Detail

Image

Caption

External phenotype and skeletal and somite defects in Pofut1^cax/Pofut1^cax mice. (A-C) Examples of homozygous mutants demonstrating the variable phenotype in the backcross progeny. (D-G) Skeletal preparations of E15.5 embryos showing that even externally apparently normal mice have skeletal defects (D), and demonstrating various defects such as split vertebrae (asterisks in D, F, G), rib fusions and bifurcations (arrowheads in F), reduced or missing pedicles (arrows in G), and axial truncations (E). White and black boxes in (E) indicate the regions shown enlarged in (F) and (G), respectively. (H, I) Sections of E9.5 mutant embryos showing distinct somite borders (indicated by arrowheads) and somites of variable size.

Copyright

This image is from Schuster-Gossler K, BMC Dev Biol 2009;9():6, an open-access article, licensee BioMed Central Ltd. J:145608

Associated Alleles

Symbol	Name
Pofut1^cax	protein O-fucosyltransferase 1; compact axial skeleton

Associated Genotypes

Allelic Composition	Genetic Background
Pofut1^cax/Pofut1^cax	C3H/HeJ-Pofut1^cax/J
Pofut1^cax/Pofut1^cax	involves: C57BL/6J * CAST/Ei