Phenotype Image Detail

Image

Caption

Altered cardiac function and arrhythmia in viable adult Smad7^tm1.1Shou/Smad7^tm1.1Shou (Smad7^deltaMH2-/-) mice. A, histological analysis showed a very thin wall in the right ventricle in adult mutant mice (at 9 months old). RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; and VS, ventricular septum. B, echocardiograph analysis of wild-type and viable mutant mice (at 3 months old, n = 5). Representative two-dimensional and M-mode images are shown. Measurement of various parameters of cardiac functions is shown in the lower panel, and * stands for p < 0.01. C, ECG analysis of wild-type and viable mutant mice (at 3 months old). Representative ECG images reveal arrhythmia (arrows) in Smad7 mutant mice.

Copyright

This image is from Chen Q, J Biol Chem 2009 Jan 2;284(1):292-300 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:145777

Associated Alleles

Symbol	Name
Smad7^tm1.1Shou	SMAD family member 7; targeted mutation 1.1, Weinian Shou

Associated Genotypes

Allelic Composition	Genetic Background
Smad7^tm1.1Shou/Smad7^tm1.1Shou	involves: C57BL/6 * FVB