Phenotype Image Detail

Image

Caption

Increased apoptosis in artioventricular cushion in Smad7^tm1.1Shou/Smad7^tm1.1Shou (Smad7^deltaMH2-/-) embryos. TUNEL assay of heart sections at E14.5 with methyl green as a counterstain. DNase I treatment was used as a positive control for TUNEL assay. Representative apoptotic cells are marked by arrows. Note that the mutant mouse displayed an increase of apoptosis-positive cells in localized regions of atrioventricular cushion in comparison with the wild-type littermate controls. RA, right atrium; LA, left atrium; AVC, atrioventricular cushion; RV, right ventricle; LV, left ventricle; and VS, ventricular septum.

Copyright

This image is from Chen Q, J Biol Chem 2009 Jan 2;284(1):292-300 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:145777

Associated Alleles

Symbol	Name
Smad7^tm1.1Shou	SMAD family member 7; targeted mutation 1.1, Weinian Shou

Associated Genotypes

Allelic Composition	Genetic Background
Smad7^tm1.1Shou/Smad7^tm1.1Shou	involves: C57BL/6 * FVB