Phenotype Image Detail

Image

Caption

Histology of the lung, spleen, and duodenum. A) Supv3l1^tm2Jkl/Supv3l1⁺ Tg(Mx1-cre)1Cgn/0 (Mx1-Cre Supv3L1^tm2Jkl/+) and B) Supv3l1^tm2Jkl/Supv3l1^tm2Jkl Tg(Mx1-cre)1Cgn/0 (Mx1-Cre Supv3L1^{tm2Jkl/tm2Jkl}) lung at 7 weeks. Note an increased number of inflammatory cells and edema. C) H&E stained section of the lung from an Supv3l1^tm2Jkl/Supv3l1^tm2Jkl Tg(CAG-cre/Esr1*)5Amc/0 (Actb-Cre Supv3L1^{tm2Jkl/tm2Jkl}) animal at the age of 12 weeks. Note the increased number of inflammatory cells, congestion, and edema. D) Lung from a control Supv3l1^tm2Jkl/Supv3l1⁺ Tg(CAG-cre/Esr1*)5Amc/0 (Actb-Cre Supv3L1^tm2Jkl/+) animal injected subcutaneously with tamoxifen at the age of 25 days. E Lung from an Supv3l1^tm2Jkl/Supv3l1^tm2Jkl Tg(CAG-cre/Esr1*)5Amc/0 (Actb-Cre Supv3L1^{tm2Jkl/tm2Jkl}) animal injected subcutaneously with tamoxifen at the age of 25 days. Note the increased number of inflammatory cells, congestion, and edema. F) H&E-stained section of the spleen from a control Supv3l1^tm2Jkl/Supv3l1⁺ Tg(Mx1-cre)1Cgn/0 (Mx1-Cre Supv3L1^tm2Jkl/+) mouse. G) Supv3l1^tm2Jkl/Supv3l1^tm2Jkl Tg(Mx1-cre)1Cgn/0 (Mx1-Cre Supv3L1^{tm2Jkl/tm2Jkl}) spleen at 7 weeks. Note splenic atrophy. H) TUNEL assay performed on a cross-section of the duodenum from an Supv3l1^tm2Jkl/Supv3l1⁺ Tg(CAG-cre/Esr1*)5Amc/0 (Actb-Cre Supv3L1^tm2Jkl/+) control littermate injected subcutaneously with tamoxifen at the age of 25 days. Note the low number of TUNEL-positive cells. I) The same assay performed on the duodenum from an Supv3l1^tm2Jkl/Supv3l1^tm2Jkl Tg(CAG-cre/Esr1*)5Amc/0 (Actb-Cre Supv3L1^{tm2Jkl/tm2Jkl}) animal also injected with tamoxifen. Note numerous TUNEL-positive cells. J) Quantification of apoptotic cells in panels H and I.

Copyright

This image is from Paul E, Mamm Genome 2009 Feb;20(2):92-108 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:144991

Associated Alleles

Symbol	Name
Supv3l1^tm2Jkl	suppressor of var1, 3-like 1 (S. cerevisiae); targeted mutation 2, Jan Klysik
Tg(CAG-cre/Esr1*)5Amc	transgene insertion 5, Andrew P McMahon
Tg(Mx1-cre)1Cgn	transgene insertion 1, University of Cologne

Associated Genotypes

Allelic Composition	Genetic Background
Supv3l1^tm2Jkl/Supv3l1^tm2Jkl Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * CBA
Supv3l1^tm2Jkl/Supv3l1^tm2Jkl Tg(CAG-cre/Esr1*)5Amc/0	involves: 129P2/OlaHsd * C57BL/6