Phenotype Image Detail

Image

Caption

(a) Hematoxylin and eosin analysis of heterozygous Bmper^tm1Cpat/Bmper⁺ (HT) lungs demonstrated delayed branching morphogenesis and inadequate expanded alveoli, which were separated by expansive interstitial mesenchyme. (b) Staining for the type II epithelial cell marker prosurfactant C (arrows). Bars, 100 uM. Positive staining is brown and counterstaining is blue. Graphical representation of the percentage of prosurfactant C-positive cells in wild-type versus heterozygous mutant lungs.

Copyright

This image is from Kelley R, J Cell Biol 2009 Feb 23;184(4):597-609, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:146800

Associated Alleles

Symbol	Name
Bmper^tm1Cpat	BMP-binding endothelial regulator; targeted mutation 1, Cam Patterson

Associated Genotypes

Allelic Composition	Genetic Background
Bmper^tm1Cpat/Bmper^+	involves: 129P2/OlaHsd * C57BL/6