Phenotype Image Detail

Image

Caption

Bmper expression (immunohistocytochemistry for GFP) and lung development were evaluated in wild-type (WT) mice versus mice with a heterozygous (HT; Bmper^tm1Cpat/Bmper⁺) inactivation of Bmper, at postnatal day 0. Heterozygous lungs showed delayed branching morphogenesis and inadequate expanded alveoli, which were separated by overgrowing GFP-positive interstitial mesenchyme. Bars, 100 uM. Positive staining is brown and counterstaining is blue. Arrows show GFP-positive mesenchymal cells. Insets show 40x.

Copyright

This image is from Kelley R, J Cell Biol 2009 Feb 23;184(4):597-609, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:146800

Associated Alleles

Symbol	Name
Bmper^tm1Cpat	BMP-binding endothelial regulator; targeted mutation 1, Cam Patterson

Associated Genotypes

Allelic Composition	Genetic Background
Bmper^tm1Cpat/Bmper^+	involves: 129P2/OlaHsd * C57BL/6