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Phenotype Image Detail
Image
Caption Cardiac phenotypes of Asxl2Gt(AQ0356)Wtsi/Asxl2Gt(AQ0356)Wtsi animals. (A, B) H&E stainings of heart sections. The myocardial fibers, composed of cardiomyocytes, are well organized in the wild-type heart (A). In contrast, the heart of a moribund 5-month-old mutant mouse shows cardiomyocyte disarray (B). (C, D) Examination of fibrosis in heart sections by Mason's trichrome (MTC) staining. Blue staining marks regions of fibrosis. The mutant (D) but not the wild-type (C) heart displays extensive interstitial fibrosis.
Copyright This image is from Baskind HA, PLoS ONE 2009;4(3):e4750, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:147372
Associated
Alleles
Symbol Name
Asxl2Gt(AQ0356)Wtsi ASXL transcriptional regulator 2; gene trap AQ0356, Wellcome Trust Sanger Institute
Associated
Genotypes
Allelic Composition Genetic Background
Asxl2Gt(AQ0356)Wtsi/Asxl2Gt(AQ0356)Wtsi involves: 129P2/OlaHsd * C57BL/6J
Asxl2Gt(AQ0356)Wtsi/Asxl2Gt(AQ0356)Wtsi B6J.129P2-Asxl2Gt(AQ0356)Wtsi

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
08/02/2024
MGI 6.24
The Jackson Laboratory