Phenotype Image Detail

Image

Caption

Cardiac phenotypes of Asxl2^{Gt(AQ0356)Wtsi}/Asxl2^{Gt(AQ0356)Wtsi} animals. (A, B) H&E stainings of heart sections. The myocardial fibers, composed of cardiomyocytes, are well organized in the wild-type heart (A). In contrast, the heart of a moribund 5-month-old mutant mouse shows cardiomyocyte disarray (B). (C, D) Examination of fibrosis in heart sections by Mason's trichrome (MTC) staining. Blue staining marks regions of fibrosis. The mutant (D) but not the wild-type (C) heart displays extensive interstitial fibrosis.

This image is from Baskind HA, PLoS ONE 2009;4(3):e4750, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:147372

Associated
Alleles

Symbol	Name
Asxl2^{Gt(AQ0356)Wtsi}	ASXL transcriptional regulator 2; gene trap AQ0356, Wellcome Trust Sanger Institute

Associated
Genotypes

Allelic Composition	Genetic Background
Asxl2^{Gt(AQ0356)Wtsi}/Asxl2^{Gt(AQ0356)Wtsi}	involves: 129P2/OlaHsd * C57BL/6J
Asxl2^{Gt(AQ0356)Wtsi}/Asxl2^{Gt(AQ0356)Wtsi}	B6J.129P2-Asxl2^{Gt(AQ0356)Wtsi}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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