Phenotype Image Detail

Image

Caption

Enhanced osteoclast formation in Ifngr1^tm1Agt/Ifngr1^tm1Agt Tg(GZMB-Tax)#Lera/0 (Tax+IFN-gamma-/-) mice. a, TRAP staining of osteoclast (OC) formation from bone marrow-derived macrophages (BMMs) after 5 days of culture in M-CSF and RANKL (bar, 50 um). b, quantification of in vitro OC numbers generated from BMMs (*, p < 0.05, ANOVA). IFN-gamma dose-dependently inhibited OC formation in vitro. TRAP stain after 5 days of BMMs cultured with M-CSF and RANKL (bar, 50 um).

Copyright

This image is from Xu Z, J Biol Chem 2009 Feb 13;284(7):4658-66 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:147601

Associated Alleles

Symbol	Name
Ifngr1^tm1Agt	interferon gamma receptor 1; targeted mutation 1, Michel Aguet
Tg(GZMB-Tax)#Lera	transgene insertion, Lee Ratner

Associated Genotypes

Allelic Composition	Genetic Background
Ifngr1^tm1Agt/Ifngr1^tm1Agt Tg(GZMB-Tax)#Lera/0	involves: 129S7/SvEvBrd * C57BL/6