Phenotype Image Detail

Image

Caption

Histological analysis of the microcystic adenomas (MCA) which developed in Vhl^tm1Lss/Vhl^tm1Lss Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre;Vhl f/f) adult pancreas. A. H&E staining of pancreas from representative control Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre; panel a), and Vhl^tm1Lss/Vhl⁺ (Vhl f/+; panel d) mice and two different Vhl^tm1Lss/Vhl^tm1Lss Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre;Vhl f/f; panels b, c, e, and f) mice at 16-18 months of age. Gross pancreas histology is shown at 40x in panels a, b, d, e, and areas (black boxes) in panels b and e are magnified at 200x in panels c and f. Islets are indicated by arrows and MCA are indicated by asterisk.

Copyright

This image is from Shen HC, PLoS ONE 2009;4(4):e4897, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:148174

Associated Alleles

Symbol	Name
Tg(Pdx1-cre)89.1Dam	transgene insertion 89.1, Douglas A Melton
Vhl^tm1Lss	von Hippel-Lindau tumor suppressor; targeted mutation 1, Laura S Schmidt

Associated Genotypes

Allelic Composition	Genetic Background
Vhl^tm1Lss/Vhl^tm1Lss Tg(Pdx1-cre)89.1Dam/0	involves: 129X1/SvJ * C57BL/6 * CBA